Drug Interaction Between Prevacid And Contrave

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Prevacid (lansoprazole) and Contrave (bupropion; naltrexone).


Can you take Prevacid while taking Contrave?

Asked by Mnl On Jul 16, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 17, 2018

There is no known drug interaction between Prevacid (lansoprazole) and Contrave (bupropion; naltrexone). They are considered safe to take together. However, it is important to follow the proper administration instructions for each drug for maximum effectiveness.

Prevacid: Administer on an empty stomach, 30—60 minutes before meals. If given once daily, administer before the first meal of the day.

Contrave: Administer by mouth in the morning and in the evening. May be administered with or without food; avoid administering with high-fat meals due to significant increases in bupropion and naltrexone systemic exposure.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

About Prevacid (Lansoprazole)

Prevacid (lansoprazole) is an acid proton-pump inhibitor (PPI). It is used for the short-term treatment of a variety of conditions including, duodenal or gastric ulcers, gastroesophageal reflux disease (GERD), and erosive esophagitis. PPIs should be administered 30 to 60 minutes before a meal for maximal pH control. While Prevacid will begin to work within 1-2 hours after taking a dose by mouth, it can sometimes take a few days for optimal effects.

About Contrave

Contrave is a combination medication, containing bupropion (an antidepressant) and naltrexone (an opioid antagonist). It is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in obese adults (BMI: > = 30 kg/m2) or in overweight adults (BMI: > = 27 kg/m2) with at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia). Contrave works by affecting areas of the brain involved in the regulation of food intake and appetite.

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