Senna (Senokot) is considered to be a "mild" stimulant laxative that is generally well tolerated if used for short periods of time.
However, long-term, or chronic use of senna can potentially cause dependence on the laxative, leading to problems with constipation when use is interrupted or stopped abruptly. This is also known as "cathartic colon". However, most studies suggest that senna has a relatively low risk of causing this would need to be used consistently for periods exceeding one year.
Senna is used to relieve occasional constipation and also for reversing the constipating effects of opioids, such as oxycodone.
Senna works by causing stimulation of smooth muscle of the colon, which increases intestinal motility. Senna is also thought to work by changing fluid balance and electrolyte absorption. It is considered a mild laxative, with an onset of action around 6 to 12 hours after taking by mouth.
Short term use of senna is generally well tolerated but can cause some of the following side effects:
- Urine discoloration
- Abdominal pain
- Loss of weight
Senna and Miralax are safe to take together. There is no interaction between the two medications. Miralax is not considered a stimulant laxative, but an osmotic laxative, that works by causing water to be retained in the stool. There is a possible risk of increased abdominal cramping and bloating when using Senna and Miralax together, but this should be minor for most individuals.