Does Grapefruit Interact With Amoxicillin?
In our latest question and answer, the pharmacist discusses whether or not grapefruit interacts with the antibiotic amoxicillin.
Hi, I was prescribed Teva-Amoxicillin for a nose infection yesterday. I've heard that some medications can have serious side effects if taken with grapefruit, I was wondering if this is one of those medications. Thanks, John
There have been no reported or documented interactions between grapefruit and amoxicillin. They are considered to be safe to take together.
Taking Amoxicillin With Grapefruit
Grapefruit can interact with a variety of medications via multiple mechanisms. These include:
- Inhibition of CYP3A metabolizing enzymes
- Inhibition of organic anion-transporting polypeptides (OATPs)
In situations where grapefruit does interact with a medication, it can take just one grapefruit or as little as one cup (i.e. 8 ounces ounces) of grapefruit juice to cause a drug interaction. Making potential interactions worse, metabolizing enzyme inhibition from grapefruit can last for over 24 hours, thus making separating medication and grapefruit/juice insignificant.
Fortunately, amoxicillin is not metabolized by anything that is affected by grapefruit/grapefruit juice, at least not significantly. They are considered safe to take together.