Does Grapefruit Interact With Amoxicillin?

In our latest question and answer, the pharmacist discusses whether or not grapefruit interacts with the antibiotic amoxicillin.


Hi, I was prescribed Teva-Amoxicillin for a nose infection yesterday. I've heard that some medications can have serious side effects if taken with grapefruit, I was wondering if this is one of those medications. Thanks, John

Asked by John On Mar 02, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Mar 07, 2018

There have been no reported or documented interactions between grapefruit and amoxicillin. They are considered to be safe to take together.

Taking Amoxicillin With Grapefruit

Grapefruit can interact with a variety of medications via multiple mechanisms. These include:

  • Inhibition of CYP3A metabolizing enzymes
  • Inhibition of organic anion-transporting polypeptides (OATPs)

In situations where grapefruit does interact with a medication, it can take just one grapefruit or as little as one cup (i.e. 8 ounces ounces) of grapefruit juice to cause a drug interaction. Making potential interactions worse, metabolizing enzyme inhibition from grapefruit can last for over 24 hours, thus making separating medication and grapefruit/juice insignificant.

Fortunately, amoxicillin is not metabolized by anything that is affected by grapefruit/grapefruit juice, at least not significantly. They are considered safe to take together.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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