Sexual dysfunction is a possible side effect of Effexor (venlafaxine) and is relatively common unfortunately. In fact, the medical guidelines for major depressive disorder state that sexual dysfunction is most prevalent with two classes of antidepressants, SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors), of which Effexor is included.


Sexual dysfunction with Effexor encompasses many possible symptoms, such as:

  • Libido decrease (2-8% incidence)
  • Ejaculation dysfunction (12% incidence)
  • Erectile dysfunction (6% incidence)
  • Orgasm dysfunction (2-5% incidence)


Some studies put the number of individuals experiencing some sort of sexual dysfunction on Effexor as high as 70%!


Studies show that the sexual side effects with Effexor tend to decrease over time. However, they may not completely go away unless you change therapy. Again, per the guidelines for major depressive disorder:

"If sexual dysfunction is determined to be a side effect of the antidepressant medication, a number of strategies are available, including continuing treatment to assess whether the dysfunction will disappear with time, lowering the dose, discontinuing the antidepressant, or substituting another antidepressant such as bupropion."

How Long Do The Sexual Side Effects Of Effexor Last?

While it is reported that sexual side effects tend to decrease the longer you take Effexor, it is important to know there is no well documented time-frame. For some, these side effects may decrease after 4-6 weeks of therapy and for others, it may take longer, if they go away at all.


Fortunately, if you continue with Effexor and the sexual side effects you are experiencing don't go away, they should not be permanent. Most individuals report a return to normal sexual function after discontinuation, although it has been reported to weeks to months for your body to adjust after stopping.


Lastly, there are rare reports of prolonged sexual dysfunction after discontinuation of antidepressants like Effexor. Although not well understand or well known to many medical practitioners, there is a condition that has been labeled PSSD (Post-SSRI Sexual Dysfunction). We wrote an article on this subject which can be found here: PSSD. It isn't currently a recognized diagnosis in medical guidelines but there have been a few studies exploring the subject and there are groups that are promoting awareness of the disorder.


It is important to discuss the side effects you are experiencing with your doctor so you can be appropriately evaluated.