Does Amoxicillin Interact With Grapefruit?

In our latest question and answer, the pharmacist discusses whether or not grapefruit or grapefruit juice interacts with amoxicillin.

Question

I accidentally mixed my amoxicillin 500 mg capsule with grapefruit juice. Is it still okay to take?

Asked by S99 On Jan 17, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jan 17, 2018

Amoxicillin does not have a listed or reported interaction with grapefruit juice and the combined use of both is considered to be safe.


Amoxicillin - Grapefruit Interaction

Grapefruit has notable interactions with many different medications. The interaction occurs via several different mechanisms including:

  • Inhibition of CYP3A metabolizing enzymes
  • Inhibition of organic anion-transporting polypeptides (OATPs)


Both grapefruit (the whole fruit) and the juice have been found to interact with medication. In fact, it can take just one grapefruit or as little as one cup (i.e. 8 ounces ounces) of grapefruit juice to cause a drug interaction. 


Making potential interactions worse, enzyme inhibition from grapefruit can last for over 24 hours, thus making separating medication and grapefruit/juice insignificant.


Fortunately, amoxicillin is not metabolized by anything that is affected by grapefruit/grapefruit juice, at least not significantly. They are considered safe to take together.

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Brian.Staiger@PharmacistAnswers.com Office: 716-389-3076

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