Food significantly increases the bioavailability (rate and extent of absorption) of spironolactone.  It is often recommended for patients to take the drug consistently with or without food. In one study, the presence of food did not alter the effect of spironolactone on blood pressure control or heart rate; therefore, the authors suggested spironolactone be taken with food to minimize the possibility of gastric irritation, which was observed to be common.

Food will enhance absorption when given concurrently, so I would recommend taking with the evening meal if that is OK with your and your doctor.​