The Medrol Dose Pack is a 6 day tapering dose of methylprednisolone, typically used for the treatment of allergic reactions and cough/cold symptoms.


Medrol Dose Pack Dosing

The Medrol Dose Pack contains 21 tablets, with each tablet containing 4mg of methylpredinsolone, intended to be taken over 6 days as follows:


  • Day 1: 6 Tablets
  • Day 2: 5 Tablets
  • Day 3: 4 Tablets
  • Day 4: 3 Tablets
  • Day 5: 2 Tablets
  • Day 6: 1 Tablet


While you can take each days tablets all at once, it isn't recommended. Methylprednisolone can cause nausea, stomach cramps and insomnia. Taking the entire days' worth of tablets at one time can increase the risk of these side effects.


It is generally prudent to take your daily dose in divided doses, as directed on the package.


The one caveat is that often times, individuals get their Medrol Dose Pack prescription later in the day, and should start as soon as possible. This makes it difficult or impossible to divide the first days' tablets. In this case, it makes sense to take all of the day 1 tablets at once, which will help to alleviate your symptoms quickly, and then begin dividing the doses starting with day 2.


Below, is the most commonly recommended way to take your Medrol Dose Pack:


Day 1

  • 8 mg (2 tablets) before breakfast
  • 4 mg (1 tablet) after lunch
  • 4 mg (1 tablet) after supper
  • 8 mg (2 tablets) at bedtime
  • Total of 6 tablets


If you get your prescription late in the day, you may take 24 mg (6 tablets) as a single dose. If you take all the tablets at one time, be sure to take the dose with food to minimize nausea.


Day 2

  • 4 mg (1 tablet) before breakfast
  • 4 mg (1 tablet) after lunch
  • 4 mg (1 tablet) after supper
  • 8mg (2 tablets) at bedtime
  • Total of 5 tablets


Day 3

  • 4 mg (1 tablet) before breakfast
  • 4 mg (1 tablet) after lunch
  • 4 mg (1 tablet) after supper
  • 4 mg (1 tablet) at bedtime
  • Total of 4 tablets


Day 4

  • 4 mg (1 tablet) before breakfast
  • 4 mg (1 tablet) after lunch
  • 4 mg (1 tablet) at bedtime
  • Total of 3 tablets


Day 5

  • 4 mg (1 tablet) before breakfast
  • 4 mg (1 tablet) at bedtime
  • Total of 2 tablets


Day 6

  • 4 mg (1 tablet) before breakfast
  • Total of 1 tablet


Summary

  • It is recommended to divide your daily doses of tablets from the Medrol Dose Pack as described above.
  • However, on day 1 of tablets, you may need to take the entire dose at once, depending on the time you get your prescription. This is safe but the medication should be taken with food to reduce nausea.