DayQuil With Benzonatate

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between DayQuil and benzonatate.


Can you take over the counter drugs such as Dayquil with Benzonatate?

Asked by Barbara On Mar 16, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 26, 2019
Man Coughing With Text Overlay - DayQuil With Benzonatate


There is no known interaction between DayQuil and benzonatate. They are considered safe to take together.[1]


When considering potential interactions involving DayQuil, it is important to take all of the active ingredients into account.

DayQuil is available in two versions, DayQuil, and DayQuil Severe. Both versions contain:[2]

  • Acetaminophen (analgesic)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal decongestant)

The 'Severe' version also contains guaifenesin, an expectorant which helps to thin and loosen mucus secretions.

No ingredient in DayQuil is known to interact with benzonatate.


Benzonatate is a non-narcotic medication, commonly prescribed with antibiotics to decrease the frequency of coughing. It appears to have an anesthetic effect (locally in the respiratory tract) and may also work centrally in the brain to reduce the cough reflex.[3]

Benzonatate has several potential drug interaction, including with:

  • Opioid analgesics
  • Blood pressure medications
  • Monoamine oxidase inhibitors (MAOIs)
  • Vancomycin
  • CNS depressants

In terms of using with CNS depressants, indicated doses of benzonatate may cause sedation and dizziness, but is not known to cause respiratory depression.

Nevertheless, high doses may cause shallow breathing, which is why it should be used cautiously with CNS depressants (or other drugs that can cause shallow breathing, like opioids).[4]

When it comes to the ingredients in DayQuil, there are no reported interactions with benzonatate.


There is no known interaction between benzonatate and DayQuil (or DayQuil Severe).

  1. ^ Elsevier ClinicalKey: Benzonatate Monograph. ClinicalKey
  2. ^ DayQuil Manufacturer Website.
  3. ^ Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. PubMed
  4. ^ Antitussives and substance abuse. PubMed

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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