Tylenol Tablets On A Table With Text - Can You Tylenol Cold + Flu Severe With A Z-Pack


Thanks for your question!

When it comes to drug interactions, I always try to remind people that some products have more than one drug, and that is the case with 'TYLENOL® Cold + Flu Severe Caplets'. It is important to consider all the drugs involved when answering a question concerning drug interactions.

Having said that, there is no known interaction between 'TYLENOL® Cold + Flu Severe Caplets' and a Z-Pack (which contains the drug azithromycin). They are considered safe to take together.

For your reference, Tylenol Severe Cold & Flu' contains (per caplet):

Even though these drugs are available over the counter, it doesn't mean they are without any potential drug or disease interactions. For example, dextromethorphan needs to be used cautiously in those taking certain antidepressants and phenylephrine can be dangerous in those with high blood pressure.

As stated though, there is no known interaction between a Z-Pack (azithromycin) and any of the drugs contained in 'TYLENOL® Cold + Flu Severe Caplets'.


  • There is no known drug interaction between azithromycin (the active ingredient in a 'Z-Pack) and TYLENOL® Cold + Flu Severe Caplets.

  • References
    1. Tylenol Manufacturer Website. Tylenol.com
    2. Drug Interaction Report. ClinicalKey (Subscription Required)