Can You Take Sudafed With Amoxicillin?

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Sudafed (pseudoephedrine) and amoxicillin.


Can you take amoxicillin with Sudafed (pseudoephedrine)? I am treating a sinus infection and want to make sure the combination is safe.

Asked by Donnie On Apr 05, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 05, 2018

Sudafed (pseudoephedrine) is safe to take with amoxicillin and there is no interaction between the two medications.

Using both Sudafed and amoxicillin at the same time is fairly common as Sudafed can often help alleviate the symptoms of sinusitis (e.g. congestion & sinus pressure), a common infection treated by amoxicillin. 

Sudafed PE (phenylephrine), the non-pseudoephedrine version of Sudafed, is also safe to take with amoxicillin.

Below, we provide additional information regarding Sudafed and amoxicillin.

Sudafed (Pseudoephedrine)

Sudafed (pseudoephedrine) is a 'sympathomimetic' medication, chemically similar to ephedrine. Sudafed is an effective nasal and sinus decongestant. It can also help to relieve sinus pressure.

Oral decongestant, such as Sudafed, are generally recommended over topical decongestant such as Afrin as oral decongestant are not typically associated with rebound congestion. While Sudafed is generally well tolerated, there is some concern with its use in those with hypertension (i.e. high blood pressure).

Most studies indicate that use of Sudafed in those with high blood pressure, at recommended doses, does not appear to cause significant increases in blood pressure. Nevertheless, if you do have issues with blood pressure, you should speak with your doctor before using Sudafed. Aside from increases in blood pressure, Sudafed may also cause:

  • Restlessness
  • Headache
  • Lightheadedness
  • Dizziness
  • Insomnia


Amoxicillin is an aminopenicillin antibiotic, structurally similar to penicillin. However, it has a broader spectrum of action (i.e. effective for more types of infection) than penicillin and is generally well tolerated when compared to other antibiotics.

Amoxicillin is indicated for the treatment of a variety of infections including:

  • Otitis media (ear infection)
  • Sinusitis
  • Upper respiratory infections
  • Urinary tract infections (UTIs)

Amoxicillin is generally taken for 10 to 14 days and can be given without regard to food in most cases. Outside the potential for allergic reaction, the most common side effects are:

  • Urine odor
  • Diarrhea
  • Headache
  • Nausea

Taking Amoxicillin With Sudafed

As discussed above, Sudafed (pseudoephedrine) is safe to take with amoxicillin and there is no interaction between the two.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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