Can You Take Oxycodone And Tylenol Together?

In our latest question and answer, the pharmacist discusses whether or not oxycodone can be taken with Tylenol (acetaminophen).


I just had an oxycodne at 1am for severe arthritis pain. Can I take no 5 hrs later a Tylenol and a benedryl to help me sleep

Asked by Pain girl On Feb 06, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 07, 2018

Tylenol (acetaminophen) and oxycodone may be safely taken together. There is no listed or reported interaction between the two medications.

In fact, oxycodone and Tylenol (acetaminophen) are combined in multiple prescription products including:

  • Roxicet
  • Endocet
  • Tylox
  • Percocet

If you have a prescription for oxycodone that does not contain Tylenol (acetaminophen), you may safely take it in addition to your oxycodone. If your prescription product already contains Tylenol (acetaminophen), you generally should not take any additional without first speaking with your doctor.

In regard to other oxycodone interactions, we wrote about combining it with Benadryl (diphenhydramine) in another article, which can be found here.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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