Can You Take NyQuil With Advil?

Yes, NyQuil can safely be taken with Advil (ibuprofen). The pharmacist discusses this and more in our latest question and answer.


I am looking for some some advice. I was wondering if is was okay to use NyQuil and Advil together? I use NyQuil every once in awhile to sleep and Advil I'd say every few days. I just want to make sure they are safe.

Asked by Josh On Dec 06, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Dec 06, 2018
Teaspoon Of NyQuil


NyQuil and Advil (ibuprofen) can be safely together, but it may not be necessary as NyQuil already contains the pain reliever acetaminophen (which is the active ingredient in Tylenol).

NyQuil contains 3 active ingredients (NyQuil Severe contains 4):

  • Acetaminophen (pain reliever/fever reducer)
  • Doxylamine (sedating antihistamine)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal) (NyQuil Severe)

If you are looking for pain relief in addition to help with sleeping at night, simply taking NyQuil may do the trick for you because of the acetaminophen it contains.

However, Advil (ibuprofen) is a different type of pain reliever than acetaminophen. It is an NSAID (non-steroidal anti-inflammatory drug), which help to reduce and relieve inflammation. Acetaminophen does not have anti-inflammatory properties.

There is no drug interaction between Advil and any of the ingredients in NyQuil. Taking both together would most likely provide greater pain relief than taking either alone and you will have the benefit of the anti-inflammatory effects from Advil.

In fact, there are several studies that suggest taking acetaminophen (in NyQuil) and Advil (ibuprofen) close to one another, or cycling them ever 2-3 hours, provides far better pain relief than either alone.

Be sure to always take Advil with food as it can cause an upset stomach and long term use increases the risk of stomach ulcers. Taking it every once in a while, on an as-needed basis, is generally considered to be safe.

Answer Summary

There is no drug interaction between Advil and NyQuil. They can be safely taken together. However, NyQuil already contains the analgesic acetaminophen. Therefore, taking Advil may not be necessary.

  1. ^ Alternating acetaminophen and ibuprofen. PubMed
  2. ^ NyQuil Manufacturer Website.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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