Can You Take Cold-Eeze And DayQuil Together?

There is no known drug interaction between Cold-Eeze and DayQuil.


Can you safely take Cold-Eeze with DayQuil?

Asked by Kristi On Mar 09, 2019

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Mar 09, 2019
Cold-Eeze Box

Yes, it is safe to take Cold-Eeze and DayQuil together. There is no drug interaction between them.

Drug Interactions

It's always a good idea to look into interactions between two drugs before taking them. The risk of an interaction occurring is especially increased when you are taking a product with multiple active ingredients, like DayQuil, or with an over the counter supplement, like Cold-Eeze (since it may not be as well studied).

Let's take a look at each product separately.


DayQuil contains three active ingredients:

  • Acetaminophen (analgesic)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal decongestant)

DayQuil Severe contains:

  • Acetaminophen (analgesic)
  • Dextromethorphan (cough suppressant)
  • Phenylephrine (nasal decongestant)
  • Guaifenesin (expectorant)

While each drug in DayQuil (and DayQuil Severe) have several drug interactions to be concerned with, there are no known interactions with Cold-Eeze.


Cold-Eeze contains zinc, specifically zinc gluconate glycine, and is purported to shorten the duration of a cold. It, therefore, makes sense that it would be used along with other over the counter cold medications to help with your symptoms.

Somewhat surprisingly, zinc has numerous drug interactions with both over the counter and prescription products that are important to know about.

Perhaps most notably, zinc can chelate, or bind to certain compounds, making them far less absorbable, thereby potentially decreasing their effectiveness. This is of serious concern with many drugs, including several classes of antibiotics (such as quinolones like ciprofloxacin).

Other drugs that zinc can 'chelate' include:

  • Keflex (cephalexin)
  • Tetracycline antibiotics
  • Allegra (fexofenadine)
  • Norvir (ritonavir)

It is very important to ask your pharmacist or doctor about potential interactions with zinc products before using Cold-Eeze.

As mentioned at the beginning of this answer however, there is no drug interaction between all of the active ingredients in DayQuil and the zinc contained in Cold-Eeze.

Answer Summary

There is no known drug interaction between DayQuil (including DayQuil Severe) and Cold-Eeze.


About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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