Can You Take Benadryl With Prednisone?
In our latest question and answer, the pharmacist discusses whether or not diphenhydramine (brand names Sominex, Benadryl) can be taken with the steroid prednisone.
Can you take diphenhydramine (Benadryl, Sominex) while taking prednisone?
Sominex is a brand name sleep aide that contains diphenhydramine. Diphenhydramine is also the active ingredient in Benadryl and ZzzQuil. Diphenhydramine is safe to take with prednisone, an oral corticosteroid. There is no listed or reported interaction between the two medications.
Prednisone is well known to cause insomnia and related side effects including increased energy, anxiety and excitation, in as little as one dose. As such, many individuals look to over the counter (OTC) medications to help with sleep in the evening. Fortunately, as mentioned above, diphenhydramine is safe to use with prednisone and there are no safety issues taking both together.
Diphenhydramine is a commonly used ingredients in many over the counter products including Sominex, ZzzQuil and Benadryl. It is classified as a first generation antihistamine and is very effective for the treatment of allergy symptoms and allergic reactions. As with most first generation antihistamines, it can cause pronounced sedation which is why it is used in over the counter sleep aides.
Prednisone is a corticosteroid that is used for a variety of indications. It it often utilized in short courses for the treatment of allergic reactions and for bronchitis. Even with short term use, it is well known to cause insomnia and anxiety. It is also known to cause GI upset. Taking it with food is recommended and over the counter sleep aides, such as Benadryl, can be utilized to combat insomnia.