Can You Take Benadryl Twice A Day?

In our latest question and answer, the pharmacist discusses whether or not Benadryl (diphenhydramine) can be taken twice a day.


Is it safe to take Benadryl more than once a day? I want to take in the morning and at night time.

Asked by Howard On Jul 30, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 30, 2018

Yes, Benadryl (diphenhydramine) can safely be taken more than once a day for most individuals. In fact, the product labeling for Benadryl states that it can be dosed every four to six hours, meaning that you can take up to 6 doses per day. 

For adults, you can take one to two tablets (25mg to 50mg) by mouth every four to six hours. This means you can take up to 12 tablets per day (6 doses of 2 tablets).

The directions for Benadryl line up with the typical duration of action for the drug. For most, each dose will last four to six hours. However, it is important to note that this can be prolonged in certain populations, such as in the elderly or in those with liver impairment.

Lastly, if you are taking Benadryl to prevent allergy symptoms, it may be worthwhile to look into "second-generation" antihistamines as they last longer (up to 24 hours) and are far less sedating than Benadryl. Another alternative could also be intranasal corticosteroids, such as Flonase or Nasonex. They are very effective for seasonal allergies and should not cause sedation.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Benadryl (Diphenhydramine)

Benadryl (diphenhydramine) is a first generation, sedating antihistamine (H1-blocker) of the ethanolamine class. It is available in oral, topical, and parenteral product forms. Benadryl is well known to cause significant sedation in most individuals and is commonly used in night-time sleep aids. Benadryl also has potent "drying" effects in most patients, which is why is causes dry mouth, dry eyes and constipation. The onset of action of Benadryl is around 15-30 minutes after taking by mouth, with peak effects occurring 1 to 3 hours later. The duration of action is around 4 to 6 hours, with this being prolonged in the elderly and in those with liver disease.

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