Can You Take Benadryl More Than Once A Day?

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl (diphenhyramine) more than once a day.


I took Benadryl in the morning for a mild allergic reaction and want to take it at night. Is that safe?

Asked by Napa On Apr 26, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Apr 26, 2018

Benadryl Tablets

Yes, Benadryl (diphenhydramine) can safely be taken more than once a day.

The duration of action of Benadryl is around 4 to 6 for most individuals, but can last longer in the elderly. In general, it is safe to take up to 6 tablets of Benadryl 25mg per day.

In fact, the maximum daily dose of Benadryl is 300mg per day, which equates to 50mg (two Benadryl tablets), every four hours (six times daily). 

It is important to note that Benadryl can cause considerable drowsiness and is generally reserved for the treatment of allergic reactions and insomnia. If you are looking for a medication to help with all-day seasonal allergy symptoms, second-generation antihistamines, like Claritin, may be a better choice as they last 24 hours per dose and are generally non-drowsy.


  • Benadryl can safely be taken more than once per day.
  • The maximum daily dose of Benadryl is 300mg per day.
  • Benadryl can be dosed up to 50mg, every four to six hours.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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