Can You Take Benadryl And Propranolol Together?

In our latest question and answer, the pharmacist discusses whether or not Benadryl (diphenhydramine) can be used with propranolol.


Is it safe to take propranolol & Benadryl (Nytol in the U.K)? I’ve been having trouble sleeping but don’t want to mix medications in. Are there is a reaction

Asked by Serialdan On Jan 25, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jan 26, 2018

It is safe to take Benadry/Nytol (diphenhydramine) with propranolol as there is no interaction between the two medications. 

Both Nytol and Benadryl are brand names for diphenhydramine, a sedating first generation antihistamine that is often used for allergies and insomnia. Propranolol, brand name Inderal, is a beta blocker that is indicated for a variety of conditions including angina, high blood pressure and migraine prophylaxis.

While both Benadryl and propranolol can be used together, caution is advised in regard to the potential for additive adverse reactions such as sedation and dizziness. Propranolol is known to cause sedation and orthostatic hypotension (a drop in blood pressure while standing), which can cause dizziness. Benadryl causes drowsiness as well.

As stated, there is no drug-drug interaction between Benadryl and propranolol. Just be aware of the potential sedation they can both cause.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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