Can You Open Prozac Capsules?

In our latest question and answer, the pharmacist discusses whether or not Prozac (fluoxetine) capsules can be opened.

Question

Can you open Prozac capsules? I have dysphagia and it is difficult for me to swallow the capsules.

Asked by Christine On Feb 22, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Feb 24, 2018

Prozac (fluoxetine) is available in a number of dosage forms including capsules, delayed release capsules, solution and tablets.  The non-delayed release capsule of Prozac (fluoxetine) can be opened and mixed with a food like applesauce, yogurt or pudding for patients who have dysphagia (problems swallowing). When opening a capsule and mixing it with food, it is important to then consume all of the applesauce, yogurt or pudding that the medication was mixed with.  Otherwise, the full dose of the medication will not be taken and may not be at therapeutic range. 


Medications that utilize a delayed release mechanism, like Prozac Weekly, cannot be opened and consumed with food. Doing so potentially can destroy the mechanism that allows these medications to either be protected from gastric acids or protect from irritation of the digestive tract.   So it is important to take these medications as directed.  If it is not possible to take as directed, discuss other options with your pharmacist or other health care provider.  Most likely there is an alternative than can work for you.


Prozac (fluoxetine) can be opened and mixed with food for patients who have trouble with dysphagia (problems swallowing). Other dosage forms, like Prozac Weekly, that utilize a delayed release, extended release or controlled release mechanism should not be opened and should be taken as directed.  

About the Pharmacist

Ms. Jennifer Hauder RPh

Jennifer Hauder is a registered pharmacist in the state of Illinois. She has over 10 years experience as a pharmacist in the retail and pharmacy benefit managers (PBM) settings. She became a pharmacist due to her interest in healthcare and the opportunity to help others with their healthcare needs. When not working, she enjoys spending time with her husband, three children and two black labs Lucky and Charms.

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