Can You Drink Alcohol While Taking Zofran?

In our latest question and answer, we discuss the safety considerations when combining alcohol with Zofran (ondansetron).

Question

Can you drink alcohol while taking Zofran (ondansetron)? I got it prescribed for nausea.

Asked by Jack On Dec 23, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Dec 23, 2017

While there is no listed or reported drug interaction between Zofran (ondansetron) and alcohol, both can cause similar side effects and should be used together with caution.


Zofran is a medication used for the treatment of nausea and vomiting. It is also specifically used for the prevention of nausea while on chemotherapy or radiation therapy. It is considered to be relatively safe and extremely effective when compared to older medications such as metoclopramide and promethazine.


Zofran It works as as serotonin receptor antagonist. Serotonin receptors (specifically serotonin receptor type 3) are located all over the body and transmit signals to via the central nervous system. The blocking of these receptors can lessen or eliminate symptoms of nausea and vomiting.


While Zofran is typically very well tolerated, it can cause mild sedation, fatigue and constipation. In addition, Zofran has been known to increase the likelihood of headaches. When combined with alcohol, these effects can be enhanced and it is recommended to not operate heavy machinery or partake in activities that require strict attention. So while there is no drug-drug interaction between Zofran and alcohol, the additive side effects can be concerning.


Interestingly enough, use the of Zofran has been investigated for the treatment of alcoholism. Early studies indicate that Zofran can reduce alcohol cravings and result in individuals with a family history of alcoholism to consume fewer drinks compared with a non-treatment group. These studies combined the use of Zofran and alcohol with no serious adverse events reported.

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