Tramadol With Advil (Ibuprofen)

Our pharmacist answers the latest question regarding whether or not there is an interaction between tramadol and ibuprofen.


I have been taking tramadol and I am still having pain. Can I take tramadol and ibuprofen together?

Asked by Commodore On Oct 02, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Oct 02, 2017


Yes, you can take Advil (ibuprofen) and tramadol together.

There is no known interaction between the two medications. While both medications are used for pain relief, they work by different mechanisms and will not interact with one another.

Additionally, ibuprofen has anti-inflammatory properties while tramadol does not. Using both together can have a synergistic effect.

In fact, certain studies have found that the combination of can be both safe and effective for certain individuals. 

Both drugs don't share similar side effect profiles aside from the fact that they can both cause stomach upset. It would be prudent to take them with food.

Section Summary
There is no drug interaction between Advil (ibuprofen) and tramadol.

Advil (Ibuprofen) Info

Ibuprofen (Advil) is a NSAID, Nonsteroidal Anti-inflammatory Drug. It is available over the counter in a dose of 200mg and is also available by prescription at higher strengths.

Ibuprofen (Advil) â€‹works as pain reliever, fever reducer and anti-inflammatory medicine.

While effective, all NSAID drugs carry an increased risk of certain adverse effects such as bleeding and ulceration...especially if given at high doses for long periods of time.

Tramadol (Ultram) Info

Tramadol is a pain reliever that is used for more moderate to severe pain.

It is classified as an opioid agonist, similar to hydrocodone and oxycodone, but is generally considered to be less potent than most opioid agonists.

It also works on several neurotransmitters such as serotonin and norepinephrine.  Tramadol is a controlled medication and may be habit forming with long term use.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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