Birth Control Interaction With Bactrim​

We answer our latest question regarding an interaction between the birth control Loestrin and the antibiotic Bactrim.


I currently take Loestrin 21 for birth control. Last Monday I started with UTI and took 2 doses of Bactrim (only two pills). Will this affect my birth control?

Asked by Joellen On Oct 03, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Oct 03, 2017

Taking a course of antibiotics while currently on birth control is a huge concern for many women, and for good reason! We want to protect against the serious consequence of unplanned pregnancy. Unfortunately, the answer as to whether or not antibiotics reduce the efficacy of birth control is not a simple 'yes' or 'no'. 

Before we discuss some of the evidence that is out there, please keep in mind that being on any antibiotic can cause you to feel nauseous, possibly leading to vomiting or diarrhea. This in turn could lead to poor absorption of your birth control or even missed doses.  Due to this, the general recommendation is that if you have been vomiting or have diarrhea for more than 48 hours, use a backup contraceptive until it's your symptoms resolve and you have taken 7 days of active pills.    

In terms of the drug interaction, studies have shown that most antibiotics, on average, do not significantly reduce the concentrations of oral contraceptives in the body and the efficacy of birth control pills is unchanged.

The only antibiotics that have a definitive negative affect on oral contraceptive levels, based on the data we have, are certain ones for like Rifampin. The caveat here, is that some studies note that there are a small number of individual patients who do in fact experience a significant decrease in concentrations of oral contraceptives and appear to ovulate (which birth control pills are supposed to suppress). The problem is that it is difficult to identify exactly who is susceptible.

The general consensus appears to be that most antibiotics do not pose a problem in those on birth control BUT women who may be affected are not easily identified and the true number of incidences of pregnancy while on antibiotics may be under-reported in total. Since unplanned pregnancy has major consequences, it may be prudent to use an additional method of contraception during short-term antibiotic use, just to be safe.​​​

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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