Best Time Of Day To Take Prozac (Fluoxetine)

In this article, our pharmacist discuss what the best time of day to take Prozac (fluoxetine) is.


Is there a best time of day to take Prozac? I can't take it in the morning because that's when I take my thyroid medication.

Asked by GHolt On Nov 03, 2017

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 03, 2017

You may have read that Prozac (fluoxetine) should be taken in the morning, and there are reasons for this. However, Prozac (fluoxetine) may be taken safely in the morning or evening with no difference in effectiveness.

The package insert for the medication does recommend morning dosing, as do most SSRI (Selective Serotonin Reuptake Inhibitor) medications. This is due to the typical side effects many people experience.

Two of the most common side effects to Prozac (fluoxetine) are insomnia and dry mouth. Dry mouth tends to occur more often in the evening as our salivary glands are less active at night. Morning dosing can sometimes alleviate this. Insomnia tends to be less of an issue with morning dosing as well.

However, a small percentage of people do experience fatigue and drowsiness on Prozac (fluoxetine). If this occurs, it is recommended to take the medication in the evening, about 1 to 2 hours before bedtime. In addition, due to conflicting medication administration schedules (like your current situation), it makes sense to take it in the evening.

As mentioned, there will be no difference in effectiveness, regardless of what time of day you take your dose. Just be sure to remain consistent. 

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Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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