Benadryl and Cymbalta do not have any drug interactions and may be taken together if symptoms dictate. However, they both have the potential to cause side effects such as drowsiness so caution should be observed if these effects are present.


What Is Cymbalta (Duloxetine)?

Cymbalta is a serotonin-norepinephrine reuptake inhibitor antidepressant most commonly used to treat depression, anxiety, and nerve pain. Cymbalta should be taken whole and may be taken with or without food. Common side effects associated with taking Cymbalta include but are not limited to:

  • Drowisiness
  • Dizziness
  • Headache
  • Nausea
  • Weight loss


What Is Benadryl (Diphenhydramine)?

Benadrylis a sedating antihistamine used most commonly for the treatment of allergic reactions, seasonal allergies, symptoms associated with the common cold and insomnia. Benadryl may be taken without regard to meals. commonly reported side effects associated with taking Benadryl include but are not limited to:

  • Drowsiness
  • Dizziness
  • Fatigue
  • Dry mouth