Baclofen With Hydrocodone Drug Interaction

In our latest question and answer, the pharmacist discusses the potential drug interaction between hydrocodone and baclofen.


I was prescribed Baclofen 10mg and Hydrocodone-Acetaminophen 5/325mg for a mechanical back injury. I’ve been reading online that there’s a major interaction between the two. Is this combination safe?

Asked by MissRose On Jun 25, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jun 26, 2018

There is a fairly significant interaction between baclofen and hydrocodone as they are both CNS (central nervous system) depressants.

Taking both together may make you feel drowsy or more tired than usual. In addition, taking both can cause:

  • Confusion
  • Dizziness
  • Extreme sleepiness
  • Lightheadedness
  • Slurred speech
  • Confusion
  • Severe weakness
  • Difficulty breathing (i.e. respiratory depression)

It is important to not drive or operate machinery until you know how these drugs affect you, especially if you take them during a time where you need to remain active (e.g. at work).

In general, if you are prescribed a skeletal muscle relaxant like baclofen and are also taking an opiate agonist like hydrocodone, you should use a lower initial dose of the skeletal muscle relaxant and titrate to clinical response. Be sure to speak with your doctor regarding appropriate dosages and use of both.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Hydrocodone

Hydrocodone is an oral semisynthetic opioid agonist and is most commonly prescribed in combination with acetaminophen, although it is available as a single ingredient in products such as Zohydro ER. Hydrocodone works by acting as a mu-receptor opioid agonist, which causes changes in the perception of pain in the central nervous system. Hydrocodone may be taken with or without food, and has an onset of action within 10-30 minutes after taking a dose by mouth. The duration of action is around 4 to 8 hours,

About Baclofen

Baclofen (BAK loe fen) is an oral skeletal muscle relaxant used to helps relieve spasms and cramping of muscles. It is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). In some individuals,baclofen also improves bowel and bladder function. After taking by mouth, baclofen begins to work in 30-60 minutes, with peak concentrations occurring 2—3 hours later. Each dose will last around 6 to 8 hours. Baclofen can be taken with or without food.

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