Azithromycin Tablet Splitting

In our latest question and answer, the pharmacist discusses whether or not azithromycin tablets can be cut or split in half.


I was recently prescribed azithromycin tablets. Even though they are pretty small, I wanted to know if they can be split

Asked by Sam On Jul 21, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Jul 21, 2018

Yes, azithromycin tablets may be safely cut or split in half if necessary. In fact, it's a common need for many individuals who have difficulty swallowing or need to administer the medication via a feeding tube.

When splitting tablets, it is important to use a pill cutter to ensure an even split and avoid crumbling. If you are not taking both halves at once, be sure to take the second-half for your next dose as it no longer will have the protective coating, making it more susceptible to environmental factors that can accelerate breakdown, such as moisture. 

Lastly, if you do not want to split azithromycin tablets, it is available in a liquid suspension dosage form, which allows you to easily measure your prescribed dose. 

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

About Azithromycin

Azithromycin (brand name Zithromax) is a semisynthetic antibiotic belonging to the macrolide family, and is similar in structure to erythromycin. However, significant differences exist as azithromycin can be dosed once daily, produces less gastrointestinal side effects and reaches higher intracellular concentrations than does erythromycin. It is used for a variety of indications including sinusitis, pneumonia, bronchitis, certain sexually transmitted diseases and tonsillitis. Azithromycin may be taken with or without food but taking it with food may improve tolerability.

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