Allegra Vs. Claritin: Which Is Better For Itching?

In our latest question and answer, the pharmacist discusses which antihistamine is more effective for itching, Allegra (fexofenadine) or Claritin (loratadine).


Will fexofenadine stop itching all over the body, better than loratadine?

Asked by Titch On May 29, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On May 29, 2018

Histamine ItchingIn regard to which is better to control itching associated with allergies, there have been few studies that directly compare Allegra (fexofenadine) and Claritin. However, in the studies that have been completed, Allegra has been shown to be more effective suppressing histamine induced inflammation than Claritin. It has also been shown to work faster than Claritin. 

One of the most common ways the effectiveness of antihistamines are tested is by evaluating how well they reduce inflammation from an induced "wheal and flare" reaction. A "wheal" is raised, red, itchy bump, which is surrounded by a reddened area, known as the “flare".

In one study, published in the Annals of Allergy, Asthma & Immunology, participants had a wheal and flare reaction induced by a skin-prick with histamine, which was then treated with either Claritin or Allegra. Allegra was shown the suppress the reaction faster than Claritin (2 hours for Allegra vs. 4 hours for Claritin) and produced greater flare suppression. The study concluded:

"In a skin test model of wheal-and-flare suppression, fexofenadine [Allegra] showed rapid distribution into the skin compartment with faster onset of action and greater potency vs loratadine [Claritin]."

Other studies, such as this one published in Clinical & Experimental Allergy and this one from the European Journal of Allergy and Clinical Immunology showed similar results. 

Not all studies agree however. One study, published in Clinical Drug Investigation, reported that Claritin was superior to Allegra in treating seasonal allergy symptoms. However, it is important to note that this study used Allegra at a dose of 60mg twice a day, which is less than the adult recommended dose of 180mg once daily.

While the studies referenced above didn't specifically test Allegra and Claritin for treatment of itching or hives, they give us a good indication that Allegra may be the better choice as it works faster and is more effective in reducing histamine induced inflammation than Claritin. Nevertheless, either will provide effective relief.

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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