Advil With Lisinopril And Hydrochlorothiazide

There is a potential interaction between all three drugs: Advil, lisinopril and hydrochlorothiazide.


I take 40mg of lisinopril 25 mg of atenol and hydrochlorothiazide 12.5 mg is it safe to take advil for pain?

Asked by deerhunter On Nov 17, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 18, 2018
Three Pill Bottles Spilling


There are a number of potential interactions between the medications you listed in your question, which are discussed below.

All the potential interaction involve adverse effects on kidney function and increases in blood pressure.

You can use our 'Drug Interaction Checker' to view these interactions as well.

Advil With Blood Pressure Meds

There is essentially a blanket warning when combining any blood pressure medication (e.g. atenolol, hydrochlorothiazide) and a NSAID (non-steroidal anti-inflammatory drug), like Advil.

From our Interaction Checker:

"Although an interaction is possible, NSAIDs and Antihypertensive agents (drugs which reduce high blood pressure) are often used together. Long-term use of NSAIDs may decrease the ability of antihypertensives to control your blood pressure, especially in older patients. If you take these drugs together for long periods, your health care provider may monitor your blood pressure more regularly to make sure it is well-controlled. If you check your own blood pressure at home and notice an increase in your blood pressure, contact your health care provider."
Gold Standard Drug Database

Essentially, all NSAIDs have been associated with increases in blood pressure as they reduce the formation of prostaglandins.

This can not only reduce kidney function but also cause:

  • Increases in blood pressure
  • Edema and weight gain

The elderly and individuals with impaired kidney function are more at risk for this interaction.

This interaction also applies to Advil with hydrochlorothiazide (in regard to a possible decrease in kidney function).

Generally, short term use of NSAIDs are perfectly fine for most individuals, but it is important to check with your doctor first.

Section Summary
Short term use of Advil and blood pressure medication is generally okay, but watch for spikes in blood pressure. Individuals with kidney impairment should speak with their doctor first.

Advil With Lisinopril

The interaction between Advil and lisinopril is similar to the general NSAID warning, but is fairly well documented.

From our Interaction Checker:

Coadministration of an NSAID and an ACE inhibitor may result in attenuated antihypertensive effects. Reversible deterioration of renal function, including acute renal failure, may also occur in renally compromised patients.
Gold Standard Drug Database

Numerous studies have explored the potential effects of NSAIDs and ACE-Inhibitors. In most individuals, the combination is okay, but, for some, it can be dangerous, especially if you are on additional medications that can affect renal function (1).

Section Summary
The combination of NSAIDs, like Advil, and ACE-Inhibitors can alter kidney function and increase blood pressure.

Additional Thoughts

As your drug interaction query involves multiple potential issues, all revolving around kidney function and increases in the blood pressure, it is important you speak with your doctor prior to using Advil.

The combination you describe (ACE-Inhibitor, diuretic such as hydrochlorothiazide and NSAID) has been labeled as the 'Triple Whammy' by some sources, and there is certainly a risk of kidney problems if they are all used together (2, 3).

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