Advil With Lisinopril And Hydrochlorothiazide

deerhunter asked

I take 40mg of lisinopril 25 mg of atenol and hydrochlorothiazide 12.5 mg. Is it safe to take Advil for pain?

Answer

There are a number of potential interactions between the medications you listed in your question, which are discussed below.

All the potential interaction involve adverse effects on kidney function and increases in blood pressure.

You can use our 'Drug Interaction Checker' to view these interactions as well.

Advil With Blood Pressure Meds

There is essentially a blanket warning when combining any blood pressure medication (e.g. atenolol, hydrochlorothiazide) and a NSAID (non-steroidal anti-inflammatory drug), like Advil.

From our Interaction Checker:

• Advil With Atenolol

"Non-steroidal anti-inflammatory drugs (NSAIDs) can produce vasoconstriction leading to an increase in blood pressure. This can increase the risk of hypertension in those being treated with beta-blocker anti-hypertensives."

Essentially, all NSAIDs have been associated with increases in blood pressure as they reduce the formation of prostaglandins.

This can not only reduce kidney function but also cause:

• Increases in blood pressure
• Edema and weight gain

The elderly and individuals with impaired kidney function are more at risk for this interaction.

This interaction also applies to Advil with hydrochlorothiazide (in regard to a possible decrease in kidney function).

Generally, short term use of NSAIDs are perfectly fine for most individuals, but it is important to check with your doctor first.

Additional Thoughts

As your drug interaction query involves multiple potential issues, all revolving around kidney function and increases in the blood pressure, it is important you speak with your doctor prior to using Advil.

The combination you describe (ACE-Inhibitor, diuretic such as hydrochlorothiazide and NSAID) has been labeled as the 'Triple Whammy' by some sources, and there is certainly a risk of kidney problems if they are all used together.