Advil Sinus Congestion & Pain With Protontix Interaction

Advil Sinus Congestion and Pain is safe to take with Protontix (pantoprazole).


Hi! Can I take Advil Sinus Congestion and Pain with Pantoprazole? Thank you.

Asked by Mel On Nov 28, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 29, 2018


Yes, Advil Sinus Congestion & Pain and Protonix (pantoprazole) may safely be taken together as there is no drug interaction between them.

Advil Sinus Congestion & Pain is a combination ingredient product, which contains the following active ingredients:

  • Ibuprofen 200mg (NSAID)
  • Phenylephrine HCI 10 mg

Both active ingredients are safe with Protonix.

It is important to note for maximum effectiveness, most sources (including the Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease) recommend to take proton pump inhibitors like Protonix (pantoprazole) on an empty stomach, 30-60 minutes before meals or other medication.

So, while you can take Advil Sinus Congestion & Pain and Protonix (pantoprazole) at the same time, you may want to consider taking Protonix first thing in the morning, by itself, for best effects.

Lastly, taking Advil Sinus Congestion & Pain intermittently and at the recommend doses is likely to be safe and effective. However, long term use of NSAIDs (like ibuprofen) have been linked to an increase risk of stomach bleeds and ulcers.

Proton pump inhibitors like Protonix can actually decrease the risk of these NSAID induced bleeding events.

In fact, the American Geriatric Society recommends the use of proton pump inhibitors in elderly individuals on long term NSAID therapy to provide gastro-protection.

Section Summary
There is no drug interaction between Advil Sinus Congestion & Pain and Protonix (pantoprazole).

About Protonix

Protonix, generic name pantoprazole (pan TOE pra zole), is a 'proton pump inhibitor', which prevent the production of acid in the stomach.

It is used to treat gastroesophageal reflux disease (GERD), inflammation of the esophagus, and Zollinger-Ellison syndrome.

Protonix is also effective in the management of duodenal ulcer or gastric ulcer, including those caused by Helicobacter pylori.

Protonix should be administered 30 to 60 minutes before a meal for maximal control of stomach acid.

While all PPI medications have similar efficacy, one advantage of Protonix is that it is reported to have fewer drug interactions than others in the class as it does not significantly inhibit hepatic CYP isoenzymes.

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