Adderall With Mucinex (Guaifenesin)

There are no known interactions between Mucinex (guaifenesin) and Adderall (amphetamine salts).


I’ve been prescribed both adderall and Guaifenesin. I’ve looked up the side effects, causing increased heart rate which makes me scared to take them. Is it okay to take 15mg of adderall in the morning, and a tablet of Guaifenesin before I go to sleep? Will this help diminish the chance of interactions?

Asked by Hailey On Nov 15, 2018

Answered by
Medical Content Reviewed By PharmacistAnswers Staff

On Nov 15, 2018
Drug Interaction Title


There are no known drug interactions between Adderall (amphetamine salts) and Mucinex (guaifenesin). They are considered safe to take together.

Additionally, Mucinex (guaifenesin) is not known to have cardiac effects and it should not potentiate or increase the risk of any such effects with Adderall.

It is important to note that there are a variety of Mucinex combination products available over the counter, including Mucinex-D, which contains:

  • Guaifenesin
  • Pseudoephedrine

Pseudoephedrine, a nasal decongestant, could potentially increase the risk of cardiac effects with Adderall and caution needs to be taken with the combination.

As stated above however, taking Mucinex (guaifenesin) alone with Adderall should not increase the risk of any of the cardiac effects you mentioned (e.g. increased heart rate).

Taking Adderall is not a contraindication for Mucinex use. So, to answer your question specifically, there shouldn't be any problems taking Adderall in the morning and Mucinex before you go to sleep.

About Adderall

Adderall contains a mixture of amphetamine and dextroamphetamine salts. It is used for the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy.

The most common adverse reactions associated with amphetamine use include:

  • Decreased appetite
  • Abdominal pain
  • Restlessness
  • Emotional changes
  • Increased heart rate

Stimulants like Adderall need to be used cautiously in those with pre-existing cardiac disease, as they may be at an increased risk for adverse events. In fact, the American Heart Association recommends careful screening of all children and adolescents prior to initiating therapy with the drug (2).

Adderall comes in both immediate release and extended release (Adderall XR) formulations.

About Mucinex

Guaifenesin is an oral expectorant, which is commonly used to treat cough due to colds and minor upper respiratory infections. It is classified as a 'mucolytic', working to loosen and thin phlegm and bronchial secretions to ease expectoration.

By reducing the viscosity (i.e. thickness) and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway. This can help to change a dry, unproductive cough to one that is more productive and less frequent.

In general, adverse reactions to guaifenesin are infrequent and usually not serious. With recommended doses, adverse effects are rare.

When given in high or excessive dosages, side effects may include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain may occur

Drowsiness, dizziness, and headache occur rarely at therapeutic doses of guaifenesin.

One potentially major adverse effect of guaifenesin is nephrolithiasis, or kidney stones. However, this has only been associated with doses far above the recommended amount (1).

There are few, if any, drug interactions associated with Mucinex (guaifenesin).

About the Pharmacist

Dr. Brian Staiger Pharm.D

Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Office: 716-389-3076

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