Drug Interaction Checker
Drug Interaction Result
Checked Drugs: Abatacept , Dextroamphetamine sulfate
Severity : moderate
Description : The metabolism of Dextroamphetamine can be increased when combined with Abatacept.
Management : When treatment with agents that reduce the cytokine levels is initiated or discontinued, monitor for reduced efficacy of CYP450 substrates such as the affected drug and adjust dosage as required.
Full Description : The physiological formation of CYP450 enzymes is inhibited by the presence of increased levels of cy... The physiological formation of CYP450 enzymes is inhibited by the presence of increased levels of cytokines produced during chronic inflammation. Hence, it is thought that these agents, by normalizing the cytokine levels, can normalize CYP450 production and activity which can interact with the metabolism of substrates of CYP enzymes. In these patients, the metabolic activity of CYP450 enzymes can be found augmented and thus, CYP450 substrates can be metabolized faster which in order can reduce its therapeutic efficacy. Read more
Information Source : DrugBank