Drug Interaction Checker
Drug Interaction Result
Checked Drugs: Pregabalin , Warfarin sodium
Severity : major
Description : The metabolism of Warfarin can be decreased when combined with Pregabalin.
Management : Avoid concomitant use of these drugs and search for treatment alternatives. If the combination cannot be avoided, monitor patient response clinically for any changes. If a change in response has been detected, suspend treatment.
Full Description : The subject drug is a CYP3A4 substrate and the affected drug is a CYP3A4 substrate with a narrow the... The subject drug is a CYP3A4 substrate and the affected drug is a CYP3A4 substrate with a narrow therapeutic index. Hence, the combination of these drugs will produce a competitive interaction that will reduce the metabolic rate of both of the drugs. It is important to keep in mind this interaction as the affected drug presents a narrow therapeutic index and thus, any changes in the serum concentration of this drug can produce major changes in the therapeutic activity or in the side effects of this drug. Read more
Information Source : DrugBank