Drug Interaction Checker

Drug Interactions Checker

Search for comprehensive interaction data on thousands of drugs. Simply type the name of a drug and select the best match from the dropdown list. You can enter as many drugs as you want. Interaction data will be displayed for all drugs entered.
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My Interactions List

Conjugated estrogens
Cimetidine hydrochloride

Drug Interaction Severity Levels

What do the drug interaction severity levels mean?
Minor
These medications may interact in a clinically significant manner. In most cases however, the benefits of combined therapy outweigh the risks. It is important to be aware of the signs and symptoms of adverse effects and discuss a monitoring plan with your doctor.
Moderate
The use of these medications together may be associated with an increased risk of side effects or unintended clinical effects. The combination should be evaluated on a case by case basis and alterations to therapy may be necessary.
Major
The use of these medications together may cause more harm than benefit. Modifications to therapy may be necessary to limit or avoid this interaction. If this combination represents your best therapy option, it is important to be monitored by your doctor.

Drug Interaction Result

Checked Drugs:
Conjugated estrogens , Cimetidine
Severity :
Moderate
Description :
Conjugated estrogens may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Management :
Monitor the patient when such drugs are given concomitantly. The monitoring of serum concentration values of the concomitantly administered agents is the only direct method to assess elimination rates or discrepancies between the agents. Adjust doses based on clinical response. Some combinations may be contraindicated. Refer to individual drug product monographs for detailed dosing or management guidelines, as they vary according to the drugs being administered.
Full Description :
The renal excretion of drugs is the overall result of a combination of processes in the kidneys that include glomerular filtration, passive diffusion, tubular secretion, as well as tubular reabsorption.[4] Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes [4], they are consequently susceptible to competition between multiple substrates that are excreted by the kidneys. If two or more medications that are mainly renally excreted are administered concomitantly, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and in the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs.[1, 2, 3, 4]
Evidence Level :
level_2

mention in the drug monograph fda

4 References
  1. 1 . Authors unspecified: Urine pH and drug excretion. Lancet. 1966 Jun 4;1(7449):1256.PubMed: 4161222
  2. 2 . Popovic B, Sutic I, Markovic NB: [NEPHROTOXIC DRUGS]. Acta Med Croatica. 2016 Dec;70(4-5):309-14.PubMed: 29087164
  3. 3 . Tiong HY, Huang P, Xiong S, Li Y, Vathsala A, Zink D: Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models. Mol Pharm. 2014 Jul 7;11(7):1933-48. doi: 10.1021/mp400720w. Epub 2014 Mar 3.PubMed: 24502545
  4. 4 . van Ginneken CA, Russel FG: Saturable pharmacokinetics in the renal excretion of drugs. Clin Pharmacokinet. 1989 Jan;16(1):38-54. doi: 10.2165/00003088-198916010-00003.PubMed: 2650954
Information Source : DrugBank

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