Drug Interaction Checker

Drug Interactions Checker

Search for comprehensive interaction data on thousands of drugs. Simply type the name of a drug and select the best match from the dropdown list. You can enter as many drugs as you want. Interaction data will be displayed for all drugs entered.
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My Interactions List

Conjugated estrogens

Drug Interaction Severity Levels

What do the drug interaction severity levels mean?
These medications may interact in a clinically significant manner. In most cases however, the benefits of combined therapy outweigh the risks. It is important to be aware of the signs and symptoms of adverse effects and discuss a monitoring plan with your doctor.
The use of these medications together may be associated with an increased risk of side effects or unintended clinical effects. The combination should be evaluated on a case by case basis and alterations to therapy may be necessary.
The use of these medications together may cause more harm than benefit. Modifications to therapy may be necessary to limit or avoid this interaction. If this combination represents your best therapy option, it is important to be monitored by your doctor.

Drug Interaction Result

Checked Drugs:
Acetaminophen , Conjugated estrogens
Severity :
Description :
The serum concentration of Conjugated estrogens can be increased when it is combined with Acetaminophen.
Management :
Due to the risk of toxicity, p-glycoprotein substrates and inhibitors coadministration should be exercised with caution. These combinations should be considered on a case by case basis depending on labeling instructions for specific drugs and the degree of p-glycoprotein inhibition.
Full Description :
This interaction may lead to increased exposure to drugs which are p-glycoprotein substrates, increasing their risk of toxicity. Central nervous system depression, undertreated HIV infection, cardiac conduction defects, and transplant rejection are all possible outcomes if these interactions occur [3].
Evidence Level :

mention in the drug monograph fda

3 References
  1. 1 . Oga EF, Sekine S, Shitara Y, Horie T: Potential P-glycoprotein-mediated drug-drug interactions of antimalarial agents in Caco-2 cells. Am J Trop Med Hyg. 2012 Jul;87(1):64-9. doi: 10.4269/ajtmh.2012.11-0817.PubMed: 22764293
  2. 2 . Verapamil FDA label File
  3. 3 . Australian prescriber: P-glycoprotein and its role in drug-drug interactions File
Information Source : DrugBank

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