Description

Simple

Clinical

Overview

Recombinant zoster vaccine, manufactured as the product Shingrix by GlaxoSmithKline, is an adjuvanted non-live recombinant vaccine indicated for prevention of shingles. First approved in October 2017 by the Food and Drug Administration, Shingrix is the preferred vaccine for preventing varicella zoster infection in people aged 50 years and older, replacing Zostavax as first line therapy[4].

Herpes zoster, also known as shingles, is caused by a reactivation of Varicella Zoster Virus (VZV), the virus that commonly causes Chickenpox in childhood. Following initial infection of VZV and resolution of Chickenpox as a child, VZV then lies dormant within the dorsal root ganglion of the central nervous sytem. Decades later, when the body's immune system weakens with age, VZV is able to reactivate and descend through the nerve cells to the surface of the skin where it causes a painful blistering rash. Risk factors for developing shingles include old age, with rates increasing substantially in person's over the age of 50, low immune function or immunosuppression, psychological stress, and diabetes. Person's living with HIV or cancer, those taking immunosuppressants, and transplant recipients are particularly at risk [3].

One of the most common complicatio... Read more

Pharmacology

Indication

Shingrix vaccine is indicated for the prevention of herpes zoster (shingles) in adults aged 50 years and older.

Pharmacodynamic

Information currently not available.

Mechanism of action

Shingrix provides protection against Herpes Zoster reactivation by eliciting an immune response to Varicella Zoster Virus (VZV). The main immunological component of Shingrix vaccine is glycoprotein E (gE), a protein found on the surface of varicella zoster virus (VZV). Immune exposure to gE protein... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Varicella Zoster Vaccine (Recombinant)
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2-Methoxyethanol
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Abatacept.
Abetimus
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Abetimus.
Acteoside
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Acteoside.
Adalimumab
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Adalimumab.
Afelimomab
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Afelimomab.
Alclometasone
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Alclometasone.
Aldesleukin
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Aldesleukin.
Aldosterone
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Aldosterone.
Alefacept
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Alefacept.
Alemtuzumab
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Alemtuzumab.
Altretamine
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Altretamine.
Amcinonide
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Amcinonide.
Amsacrine
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Amsacrine.
Anakinra
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Anakinra.
Antilymphocyte immunoglobulin (horse)
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Antilymphocyte immunoglobulin (horse).
Antithymocyte immunoglobulin (rabbit)
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Antithymocyte immunoglobulin (rabbit).
Apremilast
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Apremilast.
Arsenic trioxide
The therapeutic efficacy of Varicella Zoster Vaccine (Recombinant) can be decreased when used in combination with Arsenic trioxide.
4 References
  1. 1 . Bharucha T, Ming D, Breuer J: A critical appraisal of 'Shingrix', a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus. Hum Vaccin Immunother. 2017 Aug 3;13(8):1789-1797. doi: 10.1080/21645515.2017.1317410. Epub 2017 Apr 20.PubMed: 28426274
  2. 2 . New phase 3 data on shingles vaccine Shingrix presented at CDC Advisory Meeting. Link
  3. 3 . CDC - Clinical Overview of Shingles (Herpes Zoster) Link
  4. 4 . CDC - What Everyone Should Know about Shingles Vaccine Link