Description

Simple

A medication used to treat minor aches and pains of muscles and joints.

Clinical

A medication used to treat minor aches and pains of muscles and joints.

Overview

Capsicum oleoresin is an oily organic resin derived from the fruit of plants in the Capsicum genus, such as chilli peppers. When the plants are finely ground, capsicum oleoresin is formed after the extraction process of capsaicin using oragnic solvents such as ethanol. It is commonly used as a culinary spice. The intensity of biological actions and toxicological effects of capsicum oleoresin are a direct function of the amount of capsaicinoids, or capsaicin, present in the compound [6]. Capsaicinoids comprise of a group of fat-soluble pungent chemical phenols and include [DB06774], dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin [3]. [DB06774] and dihydrocapsaicin are the most pungent capsaicinoid analogues [3].

Capsicum oleoresin is contained in pepper sprays when suspended in water, and acts an active lachrymatory agent that induces irritation, lacrimation, pain, and temp... Read more

Pharmacology

Indication

Indicated for the temporary relief of minor aches and pains of muscles and joints associated with simple backache, arthritis, strains and sprains.

Pharmacodynamic

Capsicum oleoresin is a topical analgesic and inflammatory agent. Capsaicin, an active ingredient in capsicum oleoresin, causes pain and sensitization of both peripheral and central nerves. It induces primary and secondary hyperalgesia and mimics the symptoms associated with neuropathic pain, such a... Read more

Mechanism of action

Capsaicin is the active ingredient in capsicum oleoresin that confers the molecule its biological actions. It induces central sensitization to cause pain and depolarizes nociceptors to increases their cytosolic free Ca2+ concentration [ Read more

Absorption

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Protein binding

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Volume of distribution

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Clearance

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Half life

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Route of elimination

For pharmacokinetic properties of capsaicin, refer to the drug entry for [DB06774].

Toxicity

Acute oral LD50, acute dermal LD50 and acute inhalation LD50 in rat are >3000mg/kg, >2500 mg/kg, and >10000 mg/m^3, respectively [MSDS]. Capsicum oleoresin is not considered to be a carcinogen. There has been no case reports or findings from studies indicating teratogenic potential of capsaicinoid [... Read more

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
6 References
  1. 1 . Groninger H, Schisler RE: Topical capsaicin for neuropathic pain #255. J Palliat Med. 2012 Aug;15(8):946-7. doi: 10.1089/jpm.2012.9571.PubMed: 22849599
  2. 2 . Sricharoen P, Lamaiphan N, Patthawaro P, Limchoowong N, Techawongstien S, Chanthai S: Phytochemicals in Capsicum oleoresin from different varieties of hot chilli peppers with their antidiabetic and antioxidant activities due to some phenolic compounds. Ultrason Sonochem. 2017 Sep;38:629-639. doi: 10.1016/j.ultsonch.2016.08.018. Epub 2016 Aug 12.PubMed: 27544798
  3. 3 . Yeung MF, Tang WY: Clinicopathological effects of pepper (oleoresin capsicum) spray. Hong Kong Med J. 2015 Dec;21(6):542-52. doi: 10.12809/hkmj154691. Epub 2015 Nov 6.PubMed: 26554271
  4. 4 . O'Neill J, Brock C, Olesen AE, Andresen T, Nilsson M, Dickenson AH: Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol Rev. 2012 Oct;64(4):939-71. doi: 10.1124/pr.112.006163.PubMed: 23023032
  5. 5 . Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA, Verri WA: Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules. 2016 Jun 28;21(7). pii: molecules21070844. doi: 10.3390/molecules21070844.PubMed: 27367653
  6. 6 . Oleoresin Capsicum Toxicology Evaluation and Hazard Review Link