Description

Simple

An ingredient used in a variety of natural health products.

Clinical

An ingredient used in a variety of natural health products.

Overview

Platango seeds refer to the seeds collected from various species of plantago trees. It is found in some laxatives for treating occasional constipation and restoring regularity in bowel movements. Its potential benefit in maintaining remission in ulcerative colitis has been studied [1].

Regardless, this agent is most predominantly used as a gentle laxative agent in many parts of the world that is more commonly referred as psyllium or psyllium husk.

Pharmacology

Indication

Indications include the treatment of patients needing a high fibre regime, perhaps for: (a) the relief of constipation, including constipation in pregnancy and the maintenance of regularity; (b) the management of bowel function in patients with colostomy, ileostomy, hemorrhoids, anal fissure, chroni... Read more

Pharmacodynamic

The active ingredient psyllium husk is comprised of the episperm and collapsed adjacent layers removed from the seeds of Plantago afar L. or Plantago indica L. [3]. Psyllium husk is... Read more

Mechanism of action

Psyllium seeds are comprised of dietary fibre which, when mixed with water forms a gel-like mass that works as a mild laxative [FDA Label]. This gel-like mass subsequently moves down a patient's digestive system and makes stools softer by increasing their water contents [FDA Label]. At the same time... Read more

Absorption

Psyllium husk is capable of hydration and swelling to form a mucilage because it is only partially solubilized [3]. The polysaccharide dietary fibres of which psyllium husk is compr... Read more

Protein binding

The protein binding of psyllium husk is not formally documented at this time. Regardless, because psyllium husk is largely not adsorbed when administered, it is believed that the drug may not exhibit any kind of protein binding [ Read more

Volume of distribution

Psyllium husk when administered as intended largely undergoes little absorption into the body and plasma.

Clearance

Psyllium husk when administered as intended largely undergoes little absorption into the body and plasma.

Half life

The half-life of psyllium husk is not formally documented at this time. Regardless, because psyllium husk is largely not adsorbed when administered, it is believed that the drug may not exhibit any kind of half-life [ Read more

Route of elimination

Psyllium husk when administered as indicated is usually excreted in the faeces [ Read more

Toxicity

Overdose with psyllium husk can cause abdominal discomfort, flatulence, and/or intestinal obstruction [3].

The LD50 of psyllium husk administered orally to mice has been observed... Read more

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Plantago seed
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Plantago seed.
Aclidinium
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Aclidinium.
Agmatine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Agmatine.
Alcuronium
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Alcuronium.
Alfentanil
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Alfentanil.
Alloin
The risk or severity of adverse effects can be increased when Plantago seed is combined with Alloin.
Alphacetylmethadol
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Alphacetylmethadol.
Alphaprodine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Alphaprodine.
Amantadine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amantadine.
Amiloride
The risk or severity of adverse effects can be increased when Amiloride is combined with Plantago seed.
Amiodarone
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amiodarone.
Amitriptyline
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amitriptyline.
Amlodipine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amlodipine.
Amobarbital
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amobarbital.
Amoxapine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amoxapine.
Anisotropine methylbromide
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Anisotropine methylbromide.
Aprobarbital
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Aprobarbital.
Aranidipine
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Aranidipine.
Aripiprazole
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Aripiprazole.
Atracurium
The therapeutic efficacy of Plantago seed can be decreased when used in combination with Atracurium.
5 References
  1. 1 . Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, Navarro E, Martinez-Salmeron JF, Garcia-Puges A, Gonzalez-Huix F, Riera J, Gonzalez-Lara V, Dominguez-Abascal F, Gine JJ, Moles J, Gomollon F, Gassull MA: Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999 Feb;94(2):427-33.PubMed: 10022641
  2. 2 . Jennifer J. Yeager, Mary Beth Winton, Linda E. McCuistion, Kathleen DiMaggio (2018). Pharmacology: A Patient-Centered Nursing Process Approach. Elsevier Health Sciences.
  3. 3 . Electronic Medicines Compendium: Fybogel Orange Monograph Link
  4. 4 . Sigma Aldrich: Psyllium Profile Link
  5. 5 . European Medicines Agency: Community Herbal Monograph on Plantago afar L. et. Plantago indica L., semen Link