Description

Simple

A medication used to treat heartburn.

Clinical

An antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.

Overview

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].

Pharmacology

Indication

Used as an over the counter antacid [5].

Pharmacodynamic

Neutralizes acid in the stomach [5].

Mechanism of action

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach [5].

Absorption

About 40-60% of magnesium is absorbed following oral administration [5]. Percent absorption decreases as dose increases.

Protein binding

30% of magnesium is bound to proteins [5].

Volume of distribution

Vd for magnesium is 0.2-0.4L/kg [5]. About 50% distributes to bone.

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance [5].

Half life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult [5].

Route of elimination

Primarily eliminated in urine [5].

Toxicity

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia [5].

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Urinary Tract Infection
      • Drugbank Id: DBCOND0024122
  • Regions: US
  • Patient Conditions:
      • Name: Urinary tract extravasation
      • Drugbank Id: DBCOND0108635

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1alpha-Hydroxyvitamin D5
The serum concentration of Magnesium carbonate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The serum concentration of Magnesium carbonate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Magnesium carbonate.
2,5-Dimethoxy-4-ethylthioamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Magnesium carbonate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Magnesium carbonate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamine
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Magnesium carbonate.
Abacavir
Abacavir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Abafungin
Magnesium carbonate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acarbose
Acarbose may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Acepromazine
Magnesium carbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aceprometazine
Magnesium carbonate can cause a decrease in the absorption of Aceprometazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetaminophen
Magnesium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium carbonate.
Acetophenazine
Magnesium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigoxin
The serum concentration of Acetyldigoxin can be decreased when it is combined with Magnesium carbonate.
Aclidinium
Aclidinium may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
Acrivastine
Magnesium carbonate may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Magnesium carbonate which could result in a higher serum level.
5 References
  1. 1 . de Baaij JH: The art of magnesium transport. Magnes Res. 2015 Jul-Sep;28(3):85-91. doi: 10.1684/mrh.2015.0388.PubMed: 26446763
  2. 2 . Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163.PubMed: 26069819
  3. 3 . Nikolaev MV, Magazanik LG, Tikhonov DB: Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations. Neuropharmacology. 2012 Apr;62(5-6):2078-85. doi: 10.1016/j.neuropharm.2011.12.029. Epub 2012 Jan 12.PubMed: 22261381
  4. 4 . CDC NIOSH: MgCO3 Link
  5. 5 . Toxnet Link