Description

Simple

Clinical

Overview

Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[5] and it is the first monomeric ionic compound used as an X-ray contrast agent.[1] It was first synthesized by Wallingford in 1953[2] and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.[7] Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.[6]

Pharmacology

Indication

Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.[ Read more

Pharmacodynamic

Information currently not available.

Mechanism of action

Iodine, a big component in acetrizoic acid, is an element with a high atomic density. This property causes attenuation of X-rays within the diagnostic energy spectrum. Thus, acetrizoic acid is a water-soluble and reasonably safe iodinated contrast agent that can be intravenously administered for cli... Read more

Absorption

After intravenous administration, acetrizoic acid gets largely distributed in the extracellular fluid space.[4] Radiographic agents like acetrizoic agents present variations in the plasm... Read more

Protein binding

The radiographic agents such as acetrizoic acid are carried free in plasma in which less than 5% of the injected dose is protein bound.[9]

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

When water-soluble contrast agents, such as acetrizoic acid, are administered, it is reported a half-life of approximate 4 hours.[10]

Route of elimination

After intravenous administration, acetrizoic acid is mainly excreted unchanged by the kidney.[4] The elimination pathway is handled by a glomerular filtration and concentration by tubula... Read more

Toxicity

In preclinical studies performed in rodents, the LD50 after oral or intravenous administration was 2 g/kg and 8 g/kg respectively.[8]

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
10 References
  1. 1 . Cheng KT: N,N -Bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-glycolamidol]-2,4,6-triiodoisopht halamide .PubMed: 20641970
  2. 2 . WALLINGFORD VH: The development of organic iodine compounds as x-ray contrast media. J Am Pharm Assoc Am Pharm Assoc. 1953 Dec;42(12):721-8.PubMed: 13108780
  3. 3 . Swanson D., et al. (1990). Pharmaceuticals in medical imaging. McGraw-Hill Professional.
  4. 4 . Dawson P. (1999). Textbook of contrast media. Oxford.
  5. 5 . Acetrizoic acid Link
  6. 6 . FDA Records Link
  7. 7 . Cilag Link
  8. 8 . ChemSrc Link
  9. 9 . Radiographic constrat agents Link
  10. 10 . Water soluble contrast media Link