Polyethylene glycol


Description

Polyethylene glycol is a polyether compound used for many purposes ranging from industrial manufacturing processes to medicine. PEG is the basis of a number of laxatives (e.g., macrogol-containing products, such as Movicol and polyethylene glycol 335...

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Pharmacology

Indication

Used to treat and prevent constipation.

Pharmacodynamic

The pharmacological rationale for the use of polyethylene glycol (PEG) in gastroenterology is its in... Read more

Mechanism of action

Polyethylene glycol functions as an osmotic agent, causing excess water to be retained in the stool,... Read more

Absorption

Usually the high and intermediate molecular weight polyethylene glycol are poorly absorbed after ora... Read more

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Oral LD50 is > 50 gm/Kg in mice, rats, and rabbits.
In the event of overdosage, diarrhea would be...
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Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Abdominal fullness US
  • Kind: experimental
    • Percent: 50%
  • Clinical Trial
    Bloating US
  • Kind: experimental
    • Percent: 50%
  • Clinical Trial
    Nausea US
  • Kind: experimental
    • Percent: 50%
  • Clinical Trial
    Dermatitis US
    Clinical Trial
    Rhinorrhea US
    Clinical Trial
    Urticaria US
    Clinical Trial
    Face edema US
    Clinical Trial
    Tongue edema US
    Clinical Trial
    Angioedema US
    Clinical Trial
    Anaphylaxis US
    Clinical Trial

    Contraindications

    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Ileus
        • Drugbank Id: DBCOND0010794
    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Toxic colitis
        • Drugbank Id: DBCOND0108606
    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Toxic megacolon
        • Drugbank Id: DBCOND0096768
    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Gastrointestinal obstruction
        • Drugbank Id: DBCOND0010786
    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Bowel Perforation
        • Drugbank Id: DBCOND0062437
    • Route:
      • Oral
      • Nasogastric
    • Regions: US
    • Patient Conditions:
        • Name: Gastric Retention
        • Drugbank Id: DBCOND0088112

    Food Interactions

      Information currently not available.

    Interactions

    Type in a drug name to check for interaction with Polyethylene glycol

    The serum concentration of Abemaciclib can be increased when it is combined with Polyethylene glycol.
    The therapeutic efficacy of Abicipar Pegol can be decreased when used in combination with Polyethylene glycol.
    The serum concentration of Acebutolol can be increased when it is combined with Polyethylene glycol.
    The serum concentration of Acetaminophen can be increased when it is combined with Polyethylene glycol.
    The risk or severity of adverse effects can be increased when Acetazolamide is combined with Polyethylene glycol.
    The serum concentration of Acetyldigoxin can be decreased when it is combined with Polyethylene glycol.
    The serum concentration of Acetylsalicylic acid can be increased when it is combined with Polyethylene glycol.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Aclidinium.
    The serum concentration of Afatinib can be increased when it is combined with Polyethylene glycol.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Agmatine.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Alcuronium.
    The serum concentration of Aldosterone can be increased when it is combined with Polyethylene glycol.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Alfentanil.
    The serum concentration of Alitretinoin can be increased when it is combined with Polyethylene glycol.
    The risk or severity of adverse effects can be increased when Polyethylene glycol is combined with Alloin.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Almasilate.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Aloglutamol.
    The serum concentration of Alpelisib can be increased when it is combined with Polyethylene glycol.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Alphacetylmethadol.
    The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Alphaprodine.

    References

    • 1 . Hammer HF, Hammer J, Gasche C: [Polyethylene glycol (Macrogol)--an overview of its use in diagnosis and therapy of gastrointestinal diseases]. Wien Klin Wochenschr. 2000 Jan 28;112(2):53-60. [PubMed: 10703152]
    • 2 . Muller-Lissner S: Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):391-401. doi: 10.1517/17425255.2013.773972. Epub 2013 Feb 21. [PubMed: 23425050]
    • 3 . PLENVU (polyethylene glycol 3350, sodium sulfate, ascorbic acid, sodium chloride and potassium chloride for oral solution) US FDA 2018 Label [Link]
    • 4 . PegaLAX (polyethylene glycol 3350) 2017 Canadian Prescribing Information [Link]
    • 5 . NIH US National Library of Medicine MedlinePlus: Polyethylene Glycol 3350 Profile [Link]
    • 6 . Electronic Medicines Compendium: PegLax (Macrogol 4000) Monograph [Link]
    • 7 . NCBI StatPearls [Internet]: Bowel Preparation [Link]

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