Description

Simple

A medication used to temporarily relieve constipation and heartburn.

Clinical

An inorganic compound used as a laxative and antacid.

Overview

Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form.
Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a fire retardant.
It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers).

Pharmacology

Indication

Magnesium hydroxide can be used as an antacid or a laxative depending on the administered dose.

As an antacid, it is used for the temporary relief of heartburn, upset stomach, sour stomach or acid indigestion.

As a laxative, it is used for the relief of occasional constipation by promoting bow... Read more

Pharmacodynamic

As an antacid, magnesium hydroxide suspension neutralizes gastric acid by reacting with hydrochloric acid in the stomach to form magnesium chloride and water. It is practically insoluble in water and does not have any effect until it reacts with the hydrochloric acid in the stomach. There, it decrea... Read more

Mechanism of action

The suspension of magnesium hydroxide is ingested and enters the stomach. According to the amount ingested, the magnesium hydroxide will either act as an antacid or a laxative.

Through the ingestion of 0.5-1.5 grams (in adults) the magnesium hydroxide will act by simple acid neutralization in th... Read more

Absorption

About 15%-50% of magnesium hydroxide is absorbed very slowly through the small intestine.

Protein binding

Magnesium hydroxide does not have any protein binding properties.

Volume of distribution

The peak action and distribution of magnesium hydroxide are variable.

Clearance

Magnesium hydroxide is mainly excreted in the urine by the kidneys. Since the kidneys play a major role in its clearance, individuals with renal failure are at risk of hypermagnesemia with long term consumption as the appropriate amounts of magnesium may not be excreted.

Half life

N/A

Route of elimination

After oral administration, up to 50% of the magnesium hydroxide suspension may be absorbed as magnesium ions through the small intestines and then rapidly excreted in the urine through the kidneys. The unabsorbed drug is mainly excreted in the feces and saliva.

Toxicity

LD50=8500 mg/kg (rat, oral)

Common side effects include drowsiness or flushing (warmth, redness or tingly feeling).

Daily use of magnesium hydroxide can result in fluid and electrolyte disturbances.

Excessive use of the laxative effects of magnesium hydroxide may result in abdominal cramp... Read more

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Magnesium hydroxide
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1alpha-Hydroxyvitamin D5
The serum concentration of Magnesium hydroxide can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The serum concentration of Magnesium hydroxide can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Magnesium hydroxide.
2,5-Dimethoxy-4-ethylthioamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Magnesium hydroxide.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Magnesium hydroxide can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamine
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Magnesium hydroxide.
Abacavir
Abacavir may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Abafungin
Magnesium hydroxide can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acarbose
Acarbose may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Acepromazine
Magnesium hydroxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aceprometazine
Magnesium hydroxide can cause a decrease in the absorption of Aceprometazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetaminophen
Magnesium hydroxide can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium hydroxide.
Acetophenazine
Magnesium hydroxide can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigoxin
The serum concentration of Acetyldigoxin can be decreased when it is combined with Magnesium hydroxide.
Aclidinium
Aclidinium may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Acrivastine
Magnesium hydroxide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
4 References
  1. 1 . Drugs.com Link
  2. 2 . Glow Link
  3. 3 . Medicines Link
  4. 4 . Drugs.com Link