Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.



Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.


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Mechanism of action

Finafloxacin is a fluoroquinolone antibiotic, which selectively inhibit bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination.


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Protein binding

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Volume of distribution

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Half life

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Route of elimination

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-Finafloxacin was shown to be genotoxic and clastogenic in vitro, with and without metabolic activation, and in vivo.
-General toxicity studies in rats have confirmed sperm toxicity following oral and intravenous dosing.
-At 500 mg/kg/day, males were completely infertile, presumably... Read more

Adverse Effects


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Food Interactions

    Information currently not available.


Type in a drug name to check for interaction with Finafloxacin
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Magnesium can cause a decrease in the absorption of Finafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
1 References
  1. 1 . McKeage K: Finafloxacin: first global approval. Drugs. 2015 Apr;75(6):687-93. doi: 10.1007/s40265-015-0384-z.PubMed: 25808831