Description

Simple

Clinical

Overview

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Pharmacology

Indication

Information currently not available.

Pharmacodynamic

Information currently not available.

Mechanism of action

Information currently not available.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1-benzylimidazole
1-benzylimidazole may decrease the antihypertensive activities of Hexamethonium.
1,10-Phenanthroline
The therapeutic efficacy of Hexamethonium can be decreased when used in combination with 1,10-Phenanthroline.
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Hexamethonium.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Hexamethonium is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Hexamethonium.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Hexamethonium.
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
The risk or severity of adverse effects can be increased when 5-(2-methylpiperazine-1-sulfonyl)isoquinoline is combined with Hexamethonium.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Hexamethonium is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Hexamethonium.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Hexamethonium.
Abediterol
Abediterol may decrease the antihypertensive activities of Hexamethonium.
Acebutolol
The therapeutic efficacy of Hexamethonium can be increased when used in combination with Acebutolol.
Aceclofenac
The therapeutic efficacy of Hexamethonium can be decreased when used in combination with Aceclofenac.
Acemetacin
The therapeutic efficacy of Hexamethonium can be decreased when used in combination with Acemetacin.
Acepromazine
The risk or severity of adverse effects can be increased when Acepromazine is combined with Hexamethonium.
Aceprometazine
The risk or severity of adverse effects can be increased when Aceprometazine is combined with Hexamethonium.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Hexamethonium.
Acetophenazine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Hexamethonium.
Acetyl sulfisoxazole
The risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Hexamethonium.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Hexamethonium is combined with Acetylglycinamide chloral hydrate.
1 References
  1. 1 . Adams DJ, Bevan S, Terrar DA: Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle. Br J Pharmacol. 1991 Jan;102(1):135-45.PubMed: 1710523