Description

Simple

An antibiotic medication used to prevent bacterial infections on covered skin burn wounds.

Clinical

An antimicrobial topical agent indicated for use as an adjunctive treatment to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Overview

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.

Pharmacology

Indication

Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.[label]

Pharmacodynamic

Information currently not available.

Mechanism of action

The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.

Absorption

Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.

Toxicity

Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Mafenide
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Benzylpenicillin
Mafenide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Dapsone
The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Mafenide.
Magnesium
The serum concentration of Magnesium can be decreased when it is combined with Mafenide.
Prilocaine
The risk or severity of methemoglobinemia can be increased when Mafenide is combined with Prilocaine.
1 References
  1. 1 . Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R: Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7.PubMed: 22396671