Description

Simple

Clinical

Overview

Hexocyclium is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea. It was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. Proton pump inhibitors like [DB00338] and opiate anti-diarrheal agents like [DB00836] have largely replaced the use of anti-muscarinics in the treatment of gastric ulcers and diarrhea due to their more favorable side effect profiles.

Pharmacology

Indication

The World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders [5]. Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea.

Pharmacodynamic

Hexocyclium reduces gastrointesitinal motility and gastric acid secretion [ Read more

Mechanism of action

Hexocyclium binds to and inhibits muscarinic acetylcholine receptors [ Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1,10-Phenanthroline
The therapeutic efficacy of Hexocyclium can be decreased when used in combination with 1,10-Phenanthroline.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of Tachycardia can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Hexocyclium.
2,5-Dimethoxy-4-ethylthioamphetamine
2,5-Dimethoxy-4-ethylthioamphetamine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
4-Methoxyamphetamine
4-Methoxyamphetamine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
5-methoxy-N,N-dimethyltryptamine
5-methoxy-N,N-dimethyltryptamine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
7-Nitroindazole
7-Nitroindazole may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Abediterol
The risk or severity of Tachycardia can be increased when Hexocyclium is combined with Abediterol.
Acepromazine
Acepromazine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Aceprometazine
Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Acetazolamide
Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Acetophenazine
Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Acetylglycinamide chloral hydrate
Acetylglycinamide chloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Aclidinium
The risk or severity of adverse effects can be increased when Hexocyclium is combined with Aclidinium.
Acotiamide
The therapeutic efficacy of Hexocyclium can be decreased when used in combination with Acotiamide.
Adenosine
The risk or severity of Tachycardia can be increased when Adenosine is combined with Hexocyclium.
Adinazolam
Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Adipiplon
Adipiplon may increase the central nervous system depressant (CNS depressant) activities of Hexocyclium.
Adrafinil
The risk or severity of Tachycardia can be increased when Hexocyclium is combined with Adrafinil.
5 References
  1. 1 . Waelbroeck M, Camus J, Tastenoy M, Feifel R, Mutschler E, Tacke R, Strohmann C, Rafeiner K, Rodrigues de Miranda JF, Lambrecht G: Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes. Br J Pharmacol. 1994 Jun;112(2):505-14.PubMed: 8075869
  2. 2 . KASICH AM, FEIN HD: Hexocyclium methosulfate in active duodenal ulcer; evaluation of a new anticholinergic drug in conventional and long-acting forms, especially its effect on gastric pH as studied in 48-hour analysis. Am J Dig Dis. 1958 Jan;3(1):12-23.PubMed: 13487546
  3. 3 . Grundhofer B, Gibaldi M: Biopharmaceutic factors that influence effects of anticholinergic drugs: comparison of propantheline, hexocyclium, and isopropamide. J Pharm Sci. 1977 Oct;66(10):1433-5.PubMed: 21951
  4. 4 . Rang, H. P. and Dale, M. M. (2012). Rang and Dale's Pharmacology (7th ed.). Edinburgh: Elsevier/Churchill Livingstone.
  5. 5 . WHOCC-ATC: Hexocyclium Link