A medication used during diagnostic tests to detect types of blood cancers and damaged regions of the organ or tissue caused by inflammation.


A radiopharmaceutical agent used in the detection of the presence and extent of Hodgkin's disease, lymphoma, and bronchogenic carcinoma, as well as some acute inflammatory lesions.


Gallium citrate Ga 67 is the citrate salt of the radioisotope gallium Ga 67. Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation, allowing scintigraphic localization. Ga-67 scintigraphy (GS) cannot differentiate between tumor and acute inflammation. [NCI Thesaurus]



Gallium Citrate Ga 67 Injection may be useful to demonstrate the presence and extent of Hodgkin's disease, lymphoma, and bronchogenic carcinoma. Positive gallium Ga-67 uptake in the absence of prior symptoms warrants follow-up as an indication of a potential disease state. Gallium Citrate Ga 67 Inje... Read more


It has been reported in the scientific literature that following intravenous injection, the highest tissue concentration of gallium Ga-67 - other than tumors and sites of infection - is the renal cortex. After the first day, the maximum concentration shifts to bone and lymph nodes and after the firs... Read more

Mechanism of action

Gallium Citrate Ga 67, with no carrier added, has been found to concentrate in certain viable primary and metastatic tumors as well as focal sites of infection. The body generally handles Ga3+ as though it were ferric iron (Fe-III), and thus the free isotope ion is bound (and concentrates) in areas... Read more


The body generally handles Ga3+ as though it were ferric iron (Fe-III). However, gallium can not be reduced in vivo. Therefore, ferric ion is easily reduced and interacts with protoporphyrin IX to form heme, gallium remains bound to iron-transport proteins and carrier molecules.

Protein binding

Gallium binds to at least four iron-binding molecules: transferrin, lactoferrin, ferritin, and siderophores. Siderophores are compounds of low molecular weight that facilitate iron uptake by microorganisms.

Volume of distribution

Information currently not available.


Information currently not available.

Half life

78.26 hours

Route of elimination

No urinary excretion; elimination primarily via fecal excretion.


Information currently not available.

Adverse Effects


  • Hypersensitivity:
    • false
  • Regions: US

Food Interactions

    Information currently not available.


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4 References
  1. 1 . Hoffer P: Gallium: mechanisms. J Nucl Med. 1980 Mar;21(3):282-5.PubMed: 6988551
  2. 2 . Gallium-Mechanism article Link
  3. 3 . Gallium citrate Link
  4. 4 . Link