Description

Simple

Clinical

Overview

Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol and 75 mcg of gestodene.

Pharmacology

Indication

Information currently not available.

Pharmacodynamic

Information currently not available.

Mechanism of action

Information currently not available.

Absorption

in vitro 99% using 3H=R5020 / in vivo similar to progesterone

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

16 to 18 hrs.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
Gestodene may decrease the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Gestodene may decrease the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Gestodene.
4-Oxoretinol
The therapeutic efficacy of Gestodene can be decreased when used in combination with 4-Oxoretinol.
7-Nitroindazole
The metabolism of Gestodene can be increased when combined with 7-Nitroindazole.
Abciximab
Gestodene may decrease the anticoagulant activities of Abciximab.
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Gestodene.
Acetaminophen
The metabolism of Gestodene can be increased when combined with Acetaminophen.
Acetazolamide
The metabolism of Gestodene can be increased when combined with Acetazolamide.
Acetohexamide
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Gestodene.
Acetylsalicylic acid
Gestodene may decrease the anticoagulant activities of Acetylsalicylic acid.
Acitretin
The therapeutic efficacy of Gestodene can be decreased when used in combination with Acitretin.
Albendazole
The metabolism of Albendazole can be decreased when combined with Gestodene.
Aldosterone
The serum concentration of Aldosterone can be increased when it is combined with Gestodene.
Alfentanil
The metabolism of Alfentanil can be decreased when combined with Gestodene.
Alitretinoin
The therapeutic efficacy of Gestodene can be decreased when used in combination with Alitretinoin.
Alpelisib
The metabolism of Gestodene can be increased when combined with Alpelisib.
Alprazolam
The metabolism of Alprazolam can be decreased when combined with Gestodene.
Alteplase
Gestodene may decrease the anticoagulant activities of Alteplase.
Ambrisentan
The metabolism of Gestodene can be decreased when combined with Ambrisentan.