Description

Simple

A medication used for the treatment of heartburn and other conditions caused by stomach acid reflux, and for calcium supplementation.

Clinical

An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.

Overview

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia.

Pharmacology

Indication

For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.

Pharmacodynamic

Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, a... Read more

Mechanism of action

Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prosta... Read more

Absorption

Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.

Protein binding

Calcium acts as a co-factor to numerous enzymes.

Volume of distribution

Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Take with or without food. Food increases the absorption of calcium carbonate, which may be advantageous in its use as a calcium supplement.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with (R)-warfarin.
(S)-Warfarin
The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with (S)-Warfarin.
1alpha-Hydroxyvitamin D5
The risk or severity of adverse effects can be increased when Calcium carbonate is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The risk or severity of adverse effects can be increased when Calcium carbonate is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Calcium carbonate.
2,5-Dimethoxy-4-ethylthioamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Calcium carbonate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Calcium carbonate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamine
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Calcium carbonate.
4-hydroxycoumarin
The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with 4-hydroxycoumarin.
Abafungin
Calcium carbonate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abciximab
The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Abciximab.
Acebutolol
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate.
Acenocoumarol
The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Acenocoumarol.
Acepromazine
Calcium carbonate can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aceprometazine
Calcium carbonate can cause a decrease in the absorption of Aceprometazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetaminophen
Calcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetophenazine
Calcium carbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigitoxin
Calcium carbonate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Acetyldigoxin
Calcium carbonate may increase the arrhythmogenic activities of Acetyldigoxin.
Albaconazole
Calcium carbonate can cause a decrease in the absorption of Albaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.