Description

Simple

A medication used to treat nasal conditions leading to stuffy nose and inflammatory conditions due to allergies or colds.

Clinical

A direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds.

Overview

A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion.

Pharmacology

Indication

It is used for treating nasal congestion and minor inflammation due to allergies or colds.

Pharmacodynamic

Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion. The sympathomimetic action of xylometazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (8-12 hours) decongest... Read more

Mechanism of action

Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1-benzylimidazole
The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Xylometazoline.
2,4-thiazolidinedione
The risk or severity of hypoglycemia can be increased when Xylometazoline is combined with 2,4-thiazolidinedione.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Xylometazoline.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of hypertension can be increased when Xylometazoline is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Xylometazoline.
4-Methoxyamphetamine
The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Xylometazoline.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of hypertension can be increased when Xylometazoline is combined with 5-methoxy-N,N-dimethyltryptamine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypertensive activities of Xylometazoline.
Abafungin
The therapeutic efficacy of Abafungin can be increased when used in combination with Xylometazoline.
Abediterol
The risk or severity of hypertension can be increased when Xylometazoline is combined with Abediterol.
Acarbose
The risk or severity of hypoglycemia can be increased when Xylometazoline is combined with Acarbose.
Acebutolol
The risk or severity of bradycardia can be increased when Acebutolol is combined with Xylometazoline.
Aceclofenac
The risk or severity of hypertension can be increased when Xylometazoline is combined with Aceclofenac.
Acemetacin
The risk or severity of hypertension can be increased when Xylometazoline is combined with Acemetacin.
Acepromazine
The therapeutic efficacy of Xylometazoline can be decreased when used in combination with Acepromazine.
Acetohexamide
The risk or severity of hypoglycemia can be increased when Xylometazoline is combined with Acetohexamide.
Acetyldigitoxin
Xylometazoline may increase the arrhythmogenic activities of Acetyldigitoxin.
Acetyldigoxin
Xylometazoline may increase the arrhythmogenic activities of Acetyldigoxin.
Acetylsalicylic acid
The risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Xylometazoline.
Aclidinium
The risk or severity of Tachycardia can be increased when Xylometazoline is combined with Aclidinium.
1 References
  1. 1 . Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x.PubMed: 20030735