Description

Simple

Clinical

Overview

Pharmacology

Indication

Investigated for use/treatment in fungal infections, bacterial infection, skin infections/disorders, and onychomycosis.

Pharmacodynamic

Information currently not available.

Mechanism of action

Abafungin has been shown to have fungicidal and fungistatic effects on a wide variety of pathogens, including dermatophytes, yeasts (Candida) and moulds. The drug acts on the infecting organisms in two ways: by interfering with the formation of a vital sterol in the fungal cell membrane, thereby pre... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Abafungin.
(S)-Warfarin
The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Abafungin.
4-hydroxycoumarin
The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Abafungin.
Acenocoumarol
The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Abafungin.
Agmatine
The therapeutic efficacy of Abafungin can be increased when used in combination with Agmatine.
Almasilate
Almasilate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aloglutamol
Aloglutamol can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium
Aluminium can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium acetoacetate
Aluminium acetoacetate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium glycinate
Aluminium glycinate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphate
Aluminium phosphate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxide
Aluminum hydroxide can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amiodarone
The therapeutic efficacy of Abafungin can be increased when used in combination with Amiodarone.
Amlodipine
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Amphotericin B
The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Abafungin.
Aranidipine
The therapeutic efficacy of Abafungin can be increased when used in combination with Aranidipine.
Asenapine
Asenapine can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Atorvastatin
The risk or severity of myopathy can be increased when Abafungin is combined with Atorvastatin.
Azelnidipine
The therapeutic efficacy of Abafungin can be increased when used in combination with Azelnidipine.
Barnidipine
The therapeutic efficacy of Abafungin can be increased when used in combination with Barnidipine.
1 References
  1. 1 . Borelli C, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC: Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi. Chemotherapy. 2008;54(4):245-59. doi: 10.1159/000142334. Epub 2008 Jun 30.PubMed: 18587237