Description

Simple

Clinical

Overview

Regramostim (GM-CSF) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-α, IL-1, IL-2 and IFN-γ. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.

Pharmacology

Indication

Investigated for use/treatment in adverse effects (chemotherapy) and bone marrow transplant.

Pharmacodynamic

Information currently not available.

Mechanism of action

This drug activates mononuclear phagocytes, promotes migration of epithelial cells, and further regulates cytokine production. In 2 recent placebo-controlled studies involving venous leg ulceration, subcutaneous perilesional injections of recombinant human granulocyte-macrophage colony-stimulating f... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Regramostim
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Acebutolol
Regramostim may increase the bradycardic activities of Acebutolol.
Acetylcholine
The risk or severity of adverse effects can be increased when Regramostim is combined with Acetylcholine.
Aclidinium
The therapeutic efficacy of Aclidinium can be decreased when used in combination with Regramostim.
Agmatine
The therapeutic efficacy of Agmatine can be decreased when used in combination with Regramostim.
Alcuronium
Regramostim may decrease the neuromuscular blocking activities of Alcuronium.
Aldosterone
The therapeutic efficacy of Regramostim can be decreased when used in combination with Aldosterone.
Alprenolol
Regramostim may increase the bradycardic activities of Alprenolol.
Amantadine
The therapeutic efficacy of Amantadine can be decreased when used in combination with Regramostim.
Amifampridine
The risk or severity of adverse effects can be increased when Regramostim is combined with Amifampridine.
Amitriptyline
The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Regramostim.
Amobarbital
The therapeutic efficacy of Amobarbital can be decreased when used in combination with Regramostim.
Amoxapine
The therapeutic efficacy of Amoxapine can be decreased when used in combination with Regramostim.
Anisodamine
Regramostim may increase the bradycardic activities of Anisodamine.
Anisotropine methylbromide
The therapeutic efficacy of Anisotropine methylbromide can be decreased when used in combination with Regramostim.
Aprobarbital
The therapeutic efficacy of Aprobarbital can be decreased when used in combination with Regramostim.
Arecoline
The risk or severity of adverse effects can be increased when Regramostim is combined with Arecoline.
Aripiprazole
The therapeutic efficacy of Aripiprazole can be decreased when used in combination with Regramostim.
Arotinolol
Regramostim may increase the bradycardic activities of Arotinolol.
Atenolol
Regramostim may increase the bradycardic activities of Atenolol.
Atracurium
Regramostim may decrease the neuromuscular blocking activities of Atracurium.
2 References
  1. 1 . Sardana R, Dudani AK, Tackaberry E, Alli Z, Porter S, Rowlandson K, Ganz P, Altosaar I: Biologically active human GM-CSF produced in the seeds of transgenic rice plants. Transgenic Res. 2007 Dec;16(6):713-21. Epub 2007 Feb 16.PubMed: 17985214
  2. 2 . Rosas M, Gordon S, Taylor PR: Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice. Eur J Immunol. 2007 Sep;37(9):2518-28.PubMed: 17694571